For ICSI every motile sperm can be used. Nevertheless, the further formation of the early embryo depends on several factors, for example quality attributes of the sperm cell, which cannot be seen by light microscopy. The DNA of the sperm head might be disturbed and fragmented which results in lower pregnancy rates.

PICSI is a new method to select sperm with intact DNA. Studies have been shown that sperm with intact DNA binds to hyaluronic acid, where the cells can be separated and used for ICSI.





Further to
Polar body diagnosis